Do you experience more acne than most women your age, extra weight in your belly, unwanted hair growth or irregular periods? If so, you may be suffering from a condition called Polycystic Ovarian Syndrome (PCOS).


PCOS is a gynecological issue that affects one in 10 women. Symptoms include unwanted excess hair growth, weight gain, painful acne, and metabolic problems. Women with PCOS often have longer cycles than average (35 days or more) due to delayed ovulation. Sometimes, women with PCOS do not ovulate at all for many months. Others may have regular bleeding but no actual ovulation (anovulatory cycles). Women with PCOS often have difficulty getting pregnant, and have more pregnancy complications such as miscarriage and gestational diabetes. They are also at higher risk to develop diabetes and heart disease later in life.


The symptoms of PCOS are commonly treated with combined hormonal pills (birth control pills). This may improve symptoms like acne and hair growth, but because the pills block ovulation, women taking them may have no idea what is going on with their underlying conditions. Ultimately, hormonal pills cannot cure the problem, and they do not reduce the risk of chronic diseases in pregnancy and later in life.


At Reply, we take a different approach. Our primary goal is to help women optimize their health as much as possible. For example, even a small weight loss (10-15 pounds) can significantly improve hormone balance in some women with PCOS. Rather than prescribe hormonal pills as the first line of treatment for PCOS, we recommend treatments that promote underlying health and fertility. This might include medical treatments and/or working on lifestyle factors like diet and exercise.


As part of our care, we work to understand each patient as an individual. PCOS manifests differently in different women. This is important as every woman has a unique body and a unique cycle. Often, we target treatments to certain days during a patient’s cycle. In order to do so, the patient must be tracking her cycle. At Reply we teach fertility awareness tracking to patients who are not already able to do this. This way, women are partners with their providers in their care, and are equipped with a health tool that can serve them in many ways throughout their lifetime.


If you’ve ever struggled with irregular periods or bothersome symptoms, or been prescribed the pill for management of PCOS without being able to understand your underlying health, you may be interested in the Reply approach. We are always happy to review your symptoms, cycle history, and any hormonal tests to help customize an approach that is best for you.

To schedule an appointment at Reply, call us at 919.230.2100
or visit our Become a Patient page.

By Carolyn Plican May 30, 2025
In anticipation of an announcement from the Trump administration regarding solutions for infertility, and in preparation for World Infertility Awareness Month in June, the International Institute for Restorative Reproductive Medicine (IIRRM) has issued a statement about the growing promise and prominence of restorative reproductive medicine (RRM).
RRM parents,following years of unexplained infertility and no results working with other specialists
By Patient Testimonial May 24, 2025
Patients Erica and John found Reply following years of unexplained infertility and no results working with other specialists—“we just didn’t know there was anything else out there.” They followed the typical pattern of multiple underlying factors that could be identified and treated. With comprehensive RRM care they were able to conceive and gave birth to a healthy, beautiful baby girl. They emphasize that “if you can figure out ‘why,’ that’s half the battle.” Their testimonial below was recorded, transcribed, and edited for length.
Dr. Joseph Stanford, RRM Clinician, University of Utah
By Deborah Colloton May 24, 2025
In a first of its kind, a presidential chair in restorative reproductive medicine (RRM) has been established at the University of Utah Spencer Fox Eccles School of Medicine in Salt Lake City, Utah. This new academic chair, the “Joseph B. Stanford, M.D., and Kathleen B. Stanford Presidential Chair in Restorative Reproductive Medicine,” honors the pioneering work and commitment of Dr. and Mrs. Stanford to the RRM medical discipline.
Medical Text Books
By Deborah Colloton May 24, 2025
A major milestone for restorative reproductive medicine has been achieved with the launch of the new medical journal, Journal of Restorative Reproductive Medicine (JRRM). “Our vision is that JRRM will disseminate and promote evidence-based information to support and restore human fertility and reproductive health,” wrote editor-in-chief Dr. Joseph B. Stanford in a welcome commentary. The peer-reviewed, open-access journal is published by the International Institute for Restorative Reproductive Medicine (IIRRM), and will provide the opportunity to expand and deepen the knowledge base for restorative reproductive medicine (RRM).
Reply Fertility
By Carolyn Plican February 21, 2025
Response to Trump Executive Order on IVF: Reply Fertility Urges Restorative Reproductive Medicine for Patients Facing Infertility
A person is holding a newborn baby wearing a white hat
July 3, 2024
“After over a year of trying and a miscarriage, it just felt like there was no hope and no way out of this situation. It seemed like there was no solution, that I would always be sick, and that we would never get to hold any of our children in this life.”
By Deborah Colloton April 30, 2024
Two things struck me during reflections surrounding 2024 “National Infertility Awareness Week”:
A man and a woman are sitting on a couch talking to a woman.
August 24, 2023
Discover how restorative reproductive medicine helps couples restore natural fertility. Learn why RRM could be your answer—explore now!
By Samantha Ratcliffe, CNM, WHNP-BC February 22, 2022
”Not until I found Reply, did I feel confident that I would ever have a child of my own.” Watch to learn how the Reply Fertility “Finding and Fixing” Program helped Pamela to address her PCOS, to conceive, and to have a happy and healthy pregnancy.
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